OBJECTIVE: To introduce the research and development of systematic antifungal drugs such as imidazole,triazole,allylamine,antibiotic etc.and the marketing trend.
Tebuconazole, which belongs to triazole fungicide, can inhibit the biosynthesis of ergosterin in fungi.There are three main commercial products: Raxil, Folicur and Horizon.
Nitro 1,2,4 triazole 5 one(NTO)can be obtained by nitrating 1,2,4 triazole 3 one (TO) under different conditions,and nitrobenzyl derivatives of TO are prepared as well.