Alright the next dopamine-directed class of therapies are inhibitors of COMT, catecholamine-O-methyltransferase, which is an enzyme that degrades dopamine and levodopa.
下一个针对胺的治疗药物是COMT抑制剂;COMT,即儿茶酚胺-O-甲基转移酶,是一种可以降解胺和左旋的酶。
Motor symptoms respond to drugs used to treat Parkinson's disease, like levodopa, a dopamine analogue, while cognitive symptoms may improve with drugs for Alzheimer's disease, like donepezil, which increases acetylcholine availability.
针对运动障碍,可使用与帕金森病类似的药物,比如胺类似物左旋,而使用类似阿尔茨海默病的药物,可以改善认知症状,比如奈哌齐,它能增加乙酰胆碱的供给。
Peripheral dopa decarboxylase also exists, which can metabolize levodopa into dopamine before it gets through the blood brain barrier, and—via additional enzymes— metabolize it into other catecholamines like epinephrine, which can cause unwanted side effects like arrhythmias.
体内还有外周羧酶,可以在左旋穿过血脑屏障前将其转换为胺;然后,通过其他酶将其转换为其他儿茶酚胺,如肾上腺素,它可以导致不良的副作用,如心律失常。