Another effect of unchecked inflammation in alpha-1 antitrypsin deficiency is chronic bronchitis, resulting from increased mucus production and narrowing of the airways.
Lung diseases like chronic bronchitis, emphysema, and asthma shrink the passageways that carry oxygen, while weakening the membrane that brings oxygen into the blood.
These two are different in that chronic bronchitis is defined by clinical features, like a productive cough, whereas emphysema is defined by structural changes —specifically enlargement of the air spaces.
Other risk factors for chronic bronchitis include exposure to air pollutants like sulfur and nitrogen dioxide, exposure to dust and silica, as well as genetic factors like having a family history of chronic bronchitis.
And finally another consequence of mucus plugging in chronic bronchitis is that people can develop lung infections behind the mucus blockages in the airway, and these infections can worsen the pulmonary and cardiac symptoms.