Every year, MIT Technology Review makes a list of 10 breakthroughs we think will have a big impact on the world.
We've identified things like natural language processing, augmented reality, CRISPR, wireless charging and gene therapy before they went mainstream.
So when we heard Bill Gates was interested in helping us choose this year's list, we jumped at the chance.
Through his investing and the work of the Gates Foundation, he's thinking a lot about where technology is going and how it can do the most good for the most people.
We offered Bill a short list, he ignored it almost entirely, this list is very much his own vision.
I sat down with him to talk about what he picked.
You are famously optimistic and you know, you subscribe to the view of people like cants rustling and Steven Pinker that when you look at the important indicators, life has been getting better consistently for billions of people.
How do you sustain that kind of optimism in a world in which, you know, climate change is accelerating, we have political polarization and disruption caused by social media, we have growing economic inequality which is fueled at least in part by automation and AI.
So, there's a lot of current worries about the technology having a harmful effect, how do you retain your optimism?
It's great that people are worried about the problems, because they require action, you know, even take inequity, globally inequity is down, that is the poor countries are getting richer faster than the richer countries are getting richer.