了如指掌

She knows every nook and cranny of the city, so she’s the perfect guide.

她这个城市了如指掌，让她做向道是再好不过了。

She knows the layout of the back streets like the back of her hand.

她那的街道了如指掌。

She knows physiology from beginning to end.

她生学这门学科了如指掌。

Tony is very hot on local history.

托地历史了如指掌。