起初的

The drugs work well at first but gradually lose their effectiveness.

这些药效果起非常好，但后来逐渐失效。

At first he was most dictatorial and aggressive in what he said,but when he realised that he would get nowhere by that means,he began to sing another tune.

起说法十分专横武断,但当认识到这样做行不通候,就开始改弦易辙了。