first of all

German unity depends first of all on the German people.

德国统首先靠是德国人民。

The content of any article needs, first of all, to be relevant to the reader.

首先，任何文章内容都必须适应读者需要。

First of all, totally unlash yourself, face your work with a brand-new sight, and regard it as a good chance for practice.

首先要做件事是彻底放自己，用全新面对你现在从事工作，就当是个学习磨练好机会。