Finally, we gained four esterifiable quinolone analogues (compounds 22 to 25) by modifying the structures of compound 3, 14 and 16 on 3 position.
同时利用所合成的化合物3,14,16为模板,对它们的3位羧基进

化反
合成
4
诺酮
类化合物:化合物22—25。
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It's a multidrug resistant bacteria, and it can be treated with cephalosporins, aminoglycosides, fluoroquinolones, and carbapenems in case of beta-lactamase production; only with carbapenems in case of ESBL production; and with colistin, tigecycline or fosfomycin in case of carbapenemases production.
肺炎克雷伯杆菌也是一种多重耐
菌,如果产生β-内酰胺酶,可以用头孢菌素、氨基糖苷类、氟喹诺酮类以及碳青霉烯类


;如果产生ESBL,可以只应用碳青霉烯类进

;如果产生碳青霉烯酶,则应用多粘菌素、替加环素或磷霉素进

。