Objective To evaluate the performance of complement depend micro-lymphocytotoxicity assay (CDMA) for the detection of human leucocyte antigen-B27 (HLA-B27).
Also though, an important piece of the genetic puzzle is the Human Leucocyte Antigen system, shortened to HLA, which is this location of genes on chromosome 6 that regulate our immune functions.
Genetic risk factors include being a woman and having genes that encode a specific type of immune molecule called HLA-DR2 which is used to identify and bind to foreign molecules.
A set of genes called HLA, for instance, are involved in running the immune system, they are highly variable and mutations in them have been associated with autoimmune diseases such as type 1 diabetes.
The New York patient - who has a mixed-race ancestry - was given umbilical cord blood of an infant combined with adult stem cells, with both donors only a partial HLA match.
This was interesting because it involves the cancer cells themselves, producing a lot of immune-related messenger RNAs, things like HLA molecules, certain cytokines.
They would need to have a close enough human leukocyte antigen or HLA match to maximise the chances the transplant would work - as well as the rare genetic abnormality conferring HIV resistance.
他们需要有足够接近人类白细胞抗原或 HLA 匹配,以最大限度地提高移植成功机会——以及罕见遗传异常导致 HIV 耐药。
If the immune system comes across non-self HLA proteins, it recognises the cells displaying them as interlopers and attacks, using shock troops called killer T-cells and antibodies.
如果免疫系统遇到非HLA 蛋白,它就会将显示这些蛋白细胞识闯入者,并使用杀伤性 T 细胞和抗体突击部队发起攻击。