1.In addition, only certain murine mAb isotypes hae been shown to effectiely bind to and actiate elements of the human immune system, thereby triggering cytotoxic effector functions10.
1.另外,有些亚型的鼠单抗可有的结合并活人免疫系,发细胞毒作用[10]。
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1.So most of the mabs don't fit anymore.
大多数 mab 不再管用了。
2.To go broad. Scientists used to pick these mabs based on how strongly they attached to a particular virus.
扩大范围。以前,科学家们依据 mab 对特定病毒的附着强度来挑选药物。
3.Not yet. There are about 10 of these mabs in various stages of testing.
还不行。现在有 10 余种 mab 正处于不同阶测试中。
4.Look, I don't want to keep tossing out problems, but mabs aren't a pill like Paxlovid.
不我想不停提问,但 mab 不 Paxlovid 种药片。
5.Another advantage mabs have is they can be used to prevent infection in people who are in high-risk situations.
Mab 的另一优势可用于预防高风险群被感染。
6.In plain English that means spots that don't mutate from variant to variant, so the mabs can still lock on.
说白了就区域不会随变异株而变异,继而 mab 能一直锁定病毒。
7.They've usually got long, difficult names, but they typically end in " mab, " so that's the giveaway.
这些新药的名字一般都很长很难懂,但通常都以“mab(单克隆抗体)”结尾,因此这透露了药品配方。
8.It turns out, though, that mabs are actually cheap to produce these days, just one or two hundred bucks a pop.
但事实上,mab 现在的生产成本很低——每剂只有一两百元。
9.These mabs were configured to fit that early virus, like a key fitting into a lock.
这些 mab 为早期病毒量身打造的,就像为一把锁配的钥匙。
10.Some may be immunocompromised and don't get much benefit from vaccines, so mabs can play a prevention role for them.
其中一些可能有免疫缺陷,他们打疫苗得不到多少益处,因此 mab 便可以保护他们。
11.I saw a study in which scientists tested 21 different " mabs" against the BA. 4 and 5 variants, and only one was able to neutralize them.
我看过一项研究,说科学家们测试了 21 种 mab 对抗 BA.4 和 BA.5 变异的情况,只有一种能中和病毒。
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