SIRT1 depends on a molecule called NAD (Nicotinamide adenine dinucleotide), and NAD, in turn, depends on the substance called NMN.

SIRT1合成取决于一种叫NAD（辅酶）分子，而NAD合成则取决于一种叫NMN物质。

I take NR and NMN in an effort to increase NAD.

我服用 NR 和 NMN 来努力增加 NAD。

But NAD has not been approved by the FDA.

然而，NAD尚未获得美国食品药品监督管理局（FDA）批准。

Paxton Aaronson, too, getting his third league assist here also in the NAD VC.

帕克森·阿伦森也在这里获得了他在北美发展联赛中次助攻。

So you want to provide something that is going to increase NAD.

因此，你希望提供一种能够增加NAD（烟酰胺腺嘌呤二核苷酸）水平东西。

According to one health site, indeed this often happens when riders of bicycles or motorbikes hit their nads on the frame or a gas tank.

根据一个健康网站说法，这实经常发生在骑自行车或摩车人不小心用睾丸撞到车架或油箱时。

Is it an acute increase in NAD that, that what?

是否是NAD急剧增加，导致了什么？

NAD, short for nicotinamide adenine dinucleotide, is a coenzyme that occurs naturally in human cells.

NAD， 即烟酰胺腺嘌呤二核苷酸缩写，是一种天然存在于人体细胞中辅酶。

Then you want to make sure that the NAD to NADH recycling is on point with the electron transport chain, specifically complex one.

你需NAD到NADH循环与电子传递链，特别是复合物一， 紧密配合。

Are we observing NAD levels tapering off as we age?

我们是否观察到随着年龄增长，NAD水平逐渐下降？

Researchers theorize that increasing levels of NAD could improve cellular function and give long COVID patients more energy.

研究人员推测，提高NAD水平可能改善细胞功能，并为长新冠患者提供更多能量。

But for the purpose of how people actually do this, they intravenously get NAD because it's not orally bioavailable, or as you said, they orally take two precursors, NR and NMN.

但就人们实际操作而言，他们通过静脉注射获取NAD， 因为NAD无法通过口服有效吸收；或者如你所说， 他们口服两种前体物质，即NR和NMN。

NR and NMN are considered by many to be precursors to NAD.

许多人认为 NR 和 NMN 是 NAD 前体。

There's an enzyme called NQO1 that also helps with the recycling of NADH back into NAD.

有一种酶叫做NQO1，也有助于将NADH回收为NAD。

But when you look at the pyruvate to lactate ratio, that can give you an idea of the cytosolic NAD to NADH ratio.

但当你查看丙酮酸到乳酸比例时，这可以给你一个细胞质中烟酰胺腺嘌呤二核苷酸到还原型烟酰胺腺嘌呤二核苷酸比例概念。

And look, people may opt to do that, people with a disposable income could do that, drip it in slower, not feel nauseous, increase NAD with the hope, hope, hope that maybe it's going to extend your life.

而且，有些人可能会选择这样做，那些有可支配收入人可以这么做，他们可以缓慢地进行输液， 避免恶心感，增加NAD水平， 怀着希望、希望、再希望心情， 期待这或许能延长他们寿命。

So if the NAD to NADH ratio is high, you will have higher levels of acetones to beta hydroxybutyrate.

所以如果烟酰胺腺嘌呤二核苷酸（NAD）与还原型烟酰胺腺嘌呤二核苷酸（NADH）比例较高，你体内丙酮水平就会比β-羟基丁酸更高。

So it's going to recycle NADH back to NAD by converting the pyruvate into lactate.

所以它会通过将丙酮酸转化为乳酸，把烟酰胺腺嘌呤二核苷酸还原酶（NADH）回收成烟酰胺腺嘌呤二核苷酸（NAD）。

We're basically at the point where we're taking a lot of leaps of faith and saying, because NAD levels are going down and redox potential is going down, we believe supplementing NAD in one form or another makes sense.

我们基本上处于这样一个阶段：基于大量信仰飞跃， 我们断言，既然NAD水平和氧化还原电位都在下降，我们认为以某种形式补充NAD是有道理。

And then you want to prevent the excess of catabolism of NAD.

然后你想防止烟酰胺腺嘌呤二核苷酸过度分解。