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Their biological activity is generally attributable to inhibition of NADH: ubiquinone oxidoreductase activity and thereby mitochondrial respiration.

这一类化合物之所以具有很好的杀虫活性,是还原烟酰呤二核甘酸(NADH)的抑制作用而阻断了线粒体的呼吸。

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博兹曼科学——生物

We're storing energy as N-A-D-H NADH and F-A-D-H-2 or FADH2.

我们将能量储NADH(酰胺腺苷酸)和FADH2(黄素腺核苷酸)。

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Huberman Lab

That's the NAD, NADH, electron transport, electron accept, blah, blah, blah, blah, blah.

这就是NAD、NADH、电子传递、电子受体等一连串的过程。

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Huberman Lab

But that same study said NADH levels were going up by the same amount.

然而,同一项研究指出,NADH的水平却以相同幅度上升。

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Huberman Lab

Explain the role of NADH for people.

NADH在人体中的作用是作电子受体。

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Boost Your Biology with Lucas Aoun

And so Methadone Blue can do that as well by recycling your NAD to NADH ratio, like increase NAD.

因此,美蓝也能通过循环利用NAD与NADH的比例,即增NAD,来实现这一效果。

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博兹曼科学——生物

We've stored energy now in NADH.

我们现在将能量储在NADH中

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博兹曼科学——生物

Now the puzzle's not quite complete because we dropped off that energy of NADH and FADH2.

现在这个谜题还不完全,因我们忽略了NADH和FADH2的能量。

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Boost Your Biology with Lucas Aoun

So it's going to recycle NADH back to NAD by converting the pyruvate into lactate.

所以它会通过将丙酮酸转化乳酸,把酰胺腺核苷酸还原酶(NADH)回收成酰胺腺核苷酸(NAD)。

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Boost Your Biology with Lucas Aoun

Then NADH is transported into the mitochondria so it can go to the electron transfer chain to be recycled.

然后,NADH被转运进线粒体,以便进入电子传递链进行循环利用。

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Boost Your Biology with Lucas Aoun

If lactate is high, pyruvate is low, you likely have insufficient NAD to NADH.

如果乳酸水平高而丙酮酸水平低,很可能是因酰胺腺核苷酸(NAD)转化还原型酰胺腺核苷酸(NADH)不足。

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博兹曼科学——生物

And then this would be pyruvate and we're making ATP and we're making NADH down here as well.

然后这里会产生丙酮酸,同时我们在这里也制造了三磷酸腺苷(ATP)和还原型酰胺腺核苷酸(NADH)。

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Boost Your Biology with Lucas Aoun

So when glucose has been broken down into pyruvate via glycolysis in the cytosol, it consumes NAD to create NADH.

所以当葡萄糖在细胞质中通过糖酵解分解成丙酮酸时,会消耗酰胺腺核苷酸来生成还原型酰胺核苷酸

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Boost Your Biology with Lucas Aoun

So if the NAD to NADH ratio is high, you will have higher levels of acetones to beta hydroxybutyrate.

所以如果酰胺腺核苷酸(NAD)与还原型酰胺腺核苷酸(NADH)的比例较高,你体内的丙酮水平就会比β-羟基丁酸更高。

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Huberman Lab

So yeah, this whole NAD, NADH thing is like, you know, it's as central to our existence as any form of respiration.

所以没错, 整个NAD、NADH的过程,就像你知道的, 它对我们生的重要性不亚于任何形式的呼吸。

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Boost Your Biology with Lucas Aoun

But when you look at the pyruvate to lactate ratio, that can give you an idea of the cytosolic NAD to NADH ratio.

但当你查看丙酮酸到乳酸的比例时,这可以给你一个细胞质中酰胺腺核苷酸到还原型酰胺腺核苷酸比例的概念。

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Boost Your Biology with Lucas Aoun

There's an enzyme called NQO1 that also helps with the recycling of NADH back into NAD.

有一种酶叫做NQO1,也有助于将NADH回收NAD。

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Boost Your Biology with Lucas Aoun

If you want to look at the organic as it is, that's how you determine the NAD to NADH ratio.

如果你想直接观察有机物,那就是你确定酰胺腺核苷酸(NAD)与还原型酰胺腺核苷酸(NADH)比例的方法。

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博兹曼科学——生物

But eventually what you do is you break it into two molecules of pyruvate and you release more ATP and then a little bit of NADH.

但最终,你会将其分解成两个丙酮酸分子,并释放出更多的三磷酸腺苷(ATP),同时产生少量的酰胺腺核苷酸(NADH)。

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博兹曼科学——生物

So we're storing the energy that was found in the pyruvate in NADH and FADH2 so we can finally use that in the electron transport chain.

因此,我们将原本在于丙酮酸中的能量储NADH和FADH2中,以便最终能在电子传递链中利用这些能量。

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Boost Your Biology with Lucas Aoun

If beta hydroxybutyrate is really high, you will have, in relation to the other one, you will have high levels of NADH, right?

如果β羟基丁酸真的很高,那么相对于另一种物质,你的NADH水平也会很高, 对吧?

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3G, 401(K), a,
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