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Their biological activity is generally attributable to inhibition of NADH: ubiquinone oxidoreductase activity and thereby mitochondrial respiration.

这一物之所以具有很好的杀虫活性,是由于对还原烟酰胺腺嘌呤二核甘酸(NADH)的抑制作用而阻断了的呼吸。

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博兹曼科学——生物

We're storing energy as N-A-D-H NADH and F-A-D-H-2 or FADH2.

我们将能量储存为NADH(烟酰胺腺嘌呤二核苷酸)和FADH2(黄素腺嘌呤二核苷酸)。

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Huberman Lab

But that same study said NADH levels were going up by the same amount.

然而,同一项研究指出,NADH水平却以相同幅度上升。

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Boost Your Biology with Lucas Aoun

Then you want to make sure that the NAD to NADH recycling is on point with the electron transport chain, specifically complex one.

你需要确保NAD到NADH循环与递链,特别是复合物一, 紧密配合。

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Huberman Lab

That's the NAD, NADH, electron transport, electron accept, blah, blah, blah, blah, blah.

这就是NAD、NADH递、受体等一过程。

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博兹曼科学——生物

So we're storing the energy that was found in the pyruvate in NADH and FADH2 so we can finally use that in the electron transport chain.

因此,我们将原本存在丙酮酸中量储存在NADH和FADH2中,以便最终能在递链中利用这些能量。

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Boost Your Biology with Lucas Aoun

And so Methadone Blue can do that as well by recycling your NAD to NADH ratio, like increase NAD.

因此,美蓝也能通过循环利用NAD与NADH比例,即增加NAD,来实现这一效果。

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Huberman Lab

The story was NAD levels are going down as we age, but NADH levels are going up, suggesting that the total amount of NAD and NADH is the same.

故事是这样:随着年龄增长,NAD水平下降, 而NADH水平上升, 这表明NAD和NADH总量保持不变。

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博兹曼科学——生物

But eventually what you do is you break it into two molecules of pyruvate and you release more ATP and then a little bit of NADH.

但最终,你会将其分解成两个丙酮酸分,并释放出更多三磷酸腺苷(ATP),同时产生少量烟酰胺腺嘌呤二核苷酸(NADH)。

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There's an enzyme called NQO1 that also helps with the recycling of NADH back into NAD.

有一种酶叫做NQO1,也有助NADH回收为NAD。

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Huberman Lab

So, what NAD and NADH are doing is playing an absolutely essential to life role in facilitating the transfer of chemical energy to electrical energy back to chemical energy.

因此,NAD和NADH作用在,在促进化学能转化为能再转回化学能过程中,扮演着对生命至关重要角色。

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Boost Your Biology with Lucas Aoun

But when you look at the pyruvate to lactate ratio, that can give you an idea of the cytosolic NAD to NADH ratio.

但当你查看丙酮酸到乳酸比例时,这可以给你一个细胞质中烟酰胺腺嘌呤二核苷酸到还原型烟酰胺腺嘌呤二核苷酸比例概念。

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博兹曼科学——生物

And then this would be pyruvate and we're making ATP and we're making NADH down here as well.

然后这里会产生丙酮酸,同时我们在这里也制造了三磷酸腺苷(ATP)和还原型烟酰胺腺嘌呤二核苷酸(NADH)。

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Huberman Lab

Explain the role of NADH for people.

NADH在人体中作用是作为受体。

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Boost Your Biology with Lucas Aoun

So if the NAD to NADH ratio is high, you will have higher levels of acetones to beta hydroxybutyrate.

所以如果烟酰胺腺嘌呤二核苷酸(NAD)与还原型烟酰胺腺嘌呤二核苷酸(NADH比例较高,你体内丙酮水平就会比β-羟基丁酸更高。

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博兹曼科学——生物

We've stored energy now in NADH.

我们现在将能量储存在NADH中

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Boost Your Biology with Lucas Aoun

So it's going to recycle NADH back to NAD by converting the pyruvate into lactate.

所以它会通过将丙酮酸转化为乳酸,把烟酰胺腺嘌呤二核苷酸还原酶(NADH)回收成烟酰胺腺嘌呤二核苷酸(NAD)。

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Huberman Lab

So yeah, this whole NAD, NADH thing is like, you know, it's as central to our existence as any form of respiration.

所以没错, 整个NAD、NADH过程,就像你知道, 它对我们生存重要性不亚任何形式呼吸。

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博兹曼科学——生物

Now the puzzle's not quite complete because we dropped off that energy of NADH and FADH2.

现在这个谜题还不完全,因为我们忽略了NADH和FADH2能量。

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Boost Your Biology with Lucas Aoun

So NAD and NADH, it just like interconverts or coenzyme Q10, the reduced form, the oxidized form, it's just going to interconvert.

因此,NAD和NADH,就像辅酶Q10一样,其还原态与氧化态之间会相互转化。

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Boost Your Biology with Lucas Aoun

If you want to look at the organic as it is, that's how you determine the NAD to NADH ratio.

如果你想直接观察有机物,那就是你确定烟酰胺腺嘌呤二核苷酸(NAD)与还原型烟酰胺腺嘌呤二核苷酸(NADH)比例方法。

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