Biden first joins a meeting of the Group of 7 leading economic powers in the Bavarian Alps of Germany and later travels to Madrid for a summit with leaders of the 30 NATO countries.
There have been fractious exchanges on Tuesday between President Trump and his French counterpart Emmanuel Macron, who has said NATO is in the throes of brain death.
America does not perceive there to be a zero-sum game taking place; the United States and NATO remain committed to seeking a constructive, cooperative relationship with Russia.
NATO is still extremely active in some 4,000 U.S. troops in Poland and the Baltic states and tens of thousands on 48 hour standby bolstering NATO's allies and sending a clear message to Russia.
The NATO chief Jens Stoltenberg has said the ceasefire in northeastern Syria should serve as a basis to achieve a political settlement across the whole country.