Method The target compound was synthesized from clarithromycin via hydrolyzation,acetylation,cyclic carbonatation,oxidation,decarbonatation,acylation,cyclic carbamatation and cyclization.

方法以克拉霉素为起始原料,经水解、酰化、环碳酯化、氧化、脱碳酯化、酰化、环氨基甲酯化和环合等反应合成目标化合物。

The acetylation and deacetylation of histone is charged by a pair of protea se with antistatic function on each other,which are histone transacetylase and histone deacetylase.

组酰化和去酰化由一对功能相互拮抗的酶——组酰基转移酶和组去酰化酶负责。