Frenchman Charles Gerhardt had treated acetylchloride with sodium salicylate in 1853, but Hoffmann's version, which was instigated by his supervisor, Arthur Eichengruen, was the first to be suitable for medical use.

法国人查尔斯·格哈特在1853年曾将乙酰杨酸钠进行处理，霍夫曼的改良版，导师阿瑟·艾兴格林推动研发，是首个适合医疗用途的。