The growth,infiltration and metastasis of oncoma depend on tumor angiogenesis.Vascular endothelial growth factor(VEGF)is the most important irritant factor of angiogenesis.
Objective: To investigate the relationship of angiogenesis and microvessel density(MVD) with non-neoplastic epithelial disorders of the vulva(NNEDV) and valvar intraepithelial neoplasia(VIN).
Vascular endothelial growth factor(VEGF) is also named as vascular permeability factor(VPF),which is a powerful angiogenesis and vascular diosmosis promoter discovered at present.
So they promote angiogenesis, they promote native neurogenesis, endogenous gliogenesis, synaptogenesis, but the main benefit may be that they modulate the immune system.