Age, sex, activity, genetic phenotype, stress, disease (eg, achlorhydria, malabsorption syndromes), or previous GI surgery can affect drug bioavailability.

年龄、性别、活动情况、遗传表型、应激、疾病（如酸缺乏,营养不良综合征）或既往手术等均能响药的用度。

The transportability through BBB and bioavailability of the inhibitors will be the focus by the systemafic bioassay in vivo.

指出以后的工作重点是进行系统深入的体内评价,解决药透过血脑屏障和用度等问题。