CONCLUSION The QSAR model can predict the MIC of carbapenems and select the biologic-activity compounds, which offer a new way of thinking and references of carbapenems compounds design.
结论所建
QSAR
型能有效地进行碳青霉烯
化
物MIC值预测和化物筛选，为
药开发提供参考和思路。
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It's a multidrug resistant bacteria, and it can be treated with cephalosporins, aminoglycosides, fluoroquinolones, and carbapenems in case of beta-lactamase production; only with carbapenems in case of ESBL production; and with colistin, tigecycline or fosfomycin in case of carbapenemases production.
肺炎克雷伯杆菌
是
种多重耐药菌，如果产生β-内酰胺酶，可以用头孢菌素、氨基糖苷类、
酮类以及碳青霉烯类药
治疗；如果产生ESBL，可以只应用碳青霉烯类进行治疗；如果产生碳青霉烯酶，则应用多粘菌素、替加环素或磷霉素进行治疗。
