CONCLUSION The QSAR model can predict the MIC of carbapenems and select the biologic-activity compounds, which offer a new way of thinking and references of carbapenems compounds design.
结论所建立
QSAR模型能有效地进行碳青

化
物
MIC
预测和化
物筛选,为这
新药开发提供新
参考和思路。
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物 It's a multidrug resistant bacteria, and it can be treated with cephalosporins, aminoglycosides, fluoroquinolones, and carbapenems in case of beta-lactamase production; only with carbapenems in case of ESBL production; and with colistin, tigecycline or fosfomycin in case of carbapenemases production.
肺炎克雷伯杆菌

种多重耐药菌,如果产
β-内酰胺酶,
用头孢菌素、氨
糖苷类、氟喹诺酮类
及碳青霉烯类药物治疗;如果产
ESBL,
只应用碳青霉烯类进行治疗;如果产
碳青霉烯酶,则应用多粘菌素、替加环素或磷霉素进行治疗。
物