CONCLUSION The QSAR model can predict the MIC of carbapenems and select the biologic-activity compounds, which offer a new way of thinking and references of carbapenems compounds design.
结论所的QSAR模型能有效地进行碳青霉烯类化物的MIC值的预测和化物筛选,为这类发提供的参考和思路。
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It's a multidrug resistant bacteria, and it can be treated with cephalosporins, aminoglycosides, fluoroquinolones, and carbapenems in case of beta-lactamase production; only with carbapenems in case of ESBL production; and with colistin, tigecycline or fosfomycin in case of carbapenemases production.
肺炎克雷伯杆菌也是一种多重耐药菌,如果产生β-内酰胺,可头孢菌素、氨基糖苷类、氟喹诺酮类及碳青霉类药治疗;如果产生ESBL,可只碳青霉类进行治疗;如果产生碳青霉,则多粘菌素、替加环素或磷霉素进行治疗。