Among babies, VSDs are actually the most common congenital defect overall, but 30 to 50% of VSDs can spontaneously close during childhood, which makes ventricular defects less common with adults.
VUR can be the result of a primary congenital defect or it can be caused by bladder outlet obstruction, which increases pressure in the bladder and distorts the valve.
For example, it could be a congenital defect like spina bifida, or an acquired one like a skull fracture, where there might be CSF leaking through the sinuses.