Many of the drugs used in angina pectoris are the substrate of cytochrome P450, drug interactions are easily to occur when antianginal drugs co-administrated with other drugs and foods.
In addition, iron is also an important part of proteins like myoglobin, which delivers and stores oxygen in muscles; and mitochondrial enzymes like cytochrome oxidase, which help generate ATP.
They were able to ferry the rabbit version of the gene into the plants chromosomes and thus to engineer a type of devil's vine capable of producing cytochrome P450 2E1 To test the effectiveness of their idea.