Mr. Sabanayagam studies the epigenome as it relates to microgravity.

Sabanayagam研究了微重力下的表组基因组。

The epigenome is kinda like Play-Doh on the genome.

表观基因组有点像基因组上的橡皮泥。

After about a week the scientists take out the worms. They look for changes in the worms' epigenome.

一周后科学虫取出，然后观察虫表观基因组的改变。

And that epigenome is constantly changing.

表观基因组是不断变化的。

But in addition to the primary sequence of DNA, in addition to the As, Ts, Cs, and Gs, there's our epigenome.

但是除了 DNA 的初始序列，除了 A，T，C 和 G，还有们的表观基因组。

The epigenome can be changed by the environment. And those changes pass from one generation of worms to the next.

表观基因组可被环境改变，这些改变从一虫传递到下一。

The epigenome also mediates a lifelong dialogue between genes and the environment.

表观基因组还促成了基因与环境之间贯穿一生的对话。

So they're essentially using Evo 2 to write messages in the language of the epigenome.

所他们基本上是使用Evo 2用表观基因组的语言来写信息。

Think about developing therapies that target the epigenome.

想想开发靶向表观基因组的疗法。

So when we're young, our epigenome is pristine, it's set with genes on and genes that  are off that maintain a cell's identity.

所们年轻时，们的表观基因组是完美的，它设定了一些基因开启而一些基因关闭，维持细胞的身份。

The set of all of the chemical tags that are attached to the genome of a given cell is called the epigenome.

附着于特定细胞基因组上的所有化学标签的集合，被称为表观基因组。

From its ability to predict mutations and generate new DNA sequences, to its potential for controlling the epigenome and even designing entire organisms.

从其预测突变和生成新的DNA序列的能力，到其控制表观基因组甚至设计整个生物体的潜力。

A balanced lifestyle that includes a healthy diet, exercise, and avoiding exposure to contaminants may, in the long run, create a healthy epigenome.

均衡的生活方式，包括健康饮食、锻炼及避免接触污染物，从长远来看，可能有助于形成健康的表观基因组。

Right. But before we get too carried away with the possibilities, I want to touch upon something we discussed earlier: the epigenome.

对。但在们被这些可能性冲昏头脑之前，想谈谈们之前讨论过的事情：表观基因组。

You mentioned that Evo2 can be used to control the epigenome, that layer of control on top of DNA that influences gene expression.

你提到Evo2可用来控制表观基因组，即DNA之上的一层控制层，它影响基因表达。

Precisely. They demonstrated the effectiveness of this technique in a remarkably creative way. They actually programmed Evo2 to write simple Morse code messages into the epigenome.

正是如此。他们一种非常有创意的方式证明了这项技术的有效性。他们实际上对Evo2进行了编程，使其能够简单的摩尔斯电码信息写入表观基因组。

Each of the approximately 200 cell types in your body has essentially the same genome, but its own distinct epigenome.

你体内大约200种不同类型的细胞，虽然基因组基本相同，却各自拥有独特的表观基因组。

But again, what most people don't understand is sort of a dirty little secret is how difficult it is to measure the, and to sequence the epigenome, right?

但再次强调， 大多数人不太了解的一个不为人知的秘密是， 测量和测序表观基因组有多么困难，对吧？

Your mother's or your father's experiences as a child or choices as adults could actually shape your own epigenome.

你母亲或父亲在童年时的经历或成年后的选择，实际上能塑造你自己的表观基因组。