Behold, I will feed them with wormwood, and make them drink the water of gall: for from the prophets of Jerusalem is profaneness gone forth into all the land.
Eventually these repeated bouts of inflammation might cause the gallbladder wall to thin out and erode away completely, forming a fistula which is essentially a passageway between the gall bladder and the organ that it's stuck to.
But before the concoction in Europe of black ink from gall nuts (tumours that grow on trees where insects have laid eggs), real black was hard to conjure up.
Recycling of that heme group yields unconjugated bilirubin, which at high concentration can cause scleral icterus, jaundice, and bilirubin gall stones.