Harry Potter's loss of his parents, Katniss Everdeen's struggle against the Capitol, the heartbreaking deaths of Yuji's loved ones, much like Tanjiro with his siblings.
And doing home visits with them, it was very touching and heartbreaking to see that she was doing her best to take care of him, but really wasn't successful, and wasn't able to do it well.
Life was great until the heartbreaking death of her husband followed by her father, leaving Debbie for the first time in her life, she says, feeling lost.