Donor-cell leukemia after allogeneic hematopoietic stem cell transplantation can be an ideal model to investigate the related events in human leukemogenesis.
Hemopoietic pro-genitor cells, hematopoietic stem cells, hematopoietic microenvironment etc. show dose related damage after irradiaton, consequently, hematopoietic function is destroyed.
Now, the vast majority of bone marrow is made of hematopoietic cells which are the early progenitor cells that can differentiate into other cell types.