Method Treatment of 8,9 anhydroerythromycin 6,9 hemiketal with iodine in the alkaline solution provided corresponding N monodemethylated 12 membered ring erythromycin derivative.

方法8,9素6,9半缩酮与碘在碱性溶剂反应得到相应的N去甲基十二元素衍生物。