Since this happens within the vasculature, it's called intravascular hemolysis.

由于这种情况发生在脉管系统内，因此称作管内溶。

First, they damage the RBC membrane, resulting in intramedullary hemolysis, or RBC breakdown in the bone marrow; or extravascular hemolysis, when RBCs are destroyed by macrophages in the spleen.

首先，会破坏细胞膜，导致髓内溶（骨髓中细胞分解）或管外溶（细胞被脾脏的巨噬细胞破坏）。

It becomes treacherous for red blood cells to navigate through, and before long, they slam up against a clot and get destroyed - a process called hemolysis.

这使细胞在管中的流动变得困难；很快就会撞上栓而受损，这一过程又称“溶”。

Free hemoglobin in the plasma is bound by a molecule called haptoglobin and gets recycled, which is why a low haptoglobin level is a sign of intravascular hemolysis.

浆游离蛋白与结合珠蛋白结合，并被循环利用，这也是为何低结合珠蛋白水平是管内溶的标志之一。

With extravascular hemolysis, we have macrophages eating up red blood cells more than normal and unconjugated bilirubin production is ramped up, which is conjugated by the liver and sent to the gallbladder.

管外溶时，巨噬细胞吞噬细胞，较正常时更多，进而加速了非结合胆素的产生，非结合胆素在肝脏转变为结合胆素，并输送至胆囊。