When a catalytically active enzyme forms a complex with a cofactor a holoenzyme is produced.

酶蛋白和辅助因两者结合完整分，有活力的全酶。

Some holoenzymes, such as pyruvate dehydrogenase, are highly compex, with several cofactors.

有一些全酶是高度复杂的，如丙酮酸脱氢酶。