These are people who have not yet taken the drug metformin.

这些患者尚未开始服用二甲双胍。

It's important to understand however that all of this is new research and that these products are not interchangeable with that being said, one of these products is metformin, an FDA-approved drug that treats type 2 diabetes.

而，重要的是要明白，所有这些都是新的研究，这些产品也不能代替其中的某个产品，这些产品之一是二甲双胍，经美国食品及药物管理局批准的治疗2型糖尿病的药物。

When I took metformin, supposedly to live longer?

当我服用二甲双胍时， 据说可以活得更久？

If you have diabetes, you see the endocrinologist, you get metformin.

如你患有糖尿病，你去看内分泌科医生，得到二甲双胍。

And it lowers blood sugar just about as well as metformin does.

并它降低血糖的效和二甲双胍一样好。

I'll just be very direct and say I do not take metformin.

我非常直接地说我不服用二甲双胍。

So I ended up going on metformin, on Clomid, then I had a miscarriage, and then I had a whole period of time where I felt like I needed to get some sort of peace with my body because I felt so angry.

所以我最终开始服用二甲双胍和克罗米芬，之经历了一次流产， 接着有一段时间我感到需要与自己的身体达成某种和解， 因为我当时非常愤怒。

My rule of thumb is the worse your gut microbiome to start, the more metformin and GLP-1s can help.

我的经验法则是，肠道微生物群越差，二甲双胍和胰高血糖素样肽-1（GLP-1）药物的帮助就越大。

He has a history of hypertension and diabetes that have been well controlled with hydrochlorothiazide, Losartan, and metformin.

他有高血压和糖尿病史，通过使用氢氯噻嗪、氯沙坦和二甲双胍得到了良好控制。

The fact that people with  diabetes who were taking metformin died less than people WITHOUT diabetes is HUGE.

服用二甲双胍的糖尿病患者的死亡率比没有糖尿病的患者要少，这一事实是巨大的。

Other studies show metformin does seem  to have anti-aging effects in healthy mice and worms.

其他研究表明二甲双胍似确实对健康小鼠和蠕虫具有抗衰老作用。

So if you're interested in things like rapamycin, metformin, and whether or not fasting can improve longevity, we get into that as well.

因此， 若你对雷帕霉素、二甲双胍等药物，以及间歇性禁食是否能延长寿命感兴趣，我们也深入探讨这些话题。

Increase if growth hormone increases high dose metformin IGF one does not tend to increase, especially if insulin decreases.

如生长激素增加， 高剂量二甲双胍的情况下， 类胰岛素生长因子-1通常不增加，特别是如胰岛素水平下降的话。

However, if someone loses a, uh, a decent amount of body fat and they sleep better than their natural growth hormone production will likely go up, but metformin is not going to directly, um, increase or significantly increase growth hormone.

而，如一个人减少了相当数量的体脂并睡眠质量改善，那么他们的自生长激素分泌很可能增加。但二甲双胍并不直接或显著提升生长激素水平。

Which is interesting… But to know for sure whether metformin can actually delay aging in most people, we need more research.

这很有趣… … 但要确定二甲双胍是否真的能延缓大多数人的衰老，我们需要更多的研究。

You can take metformin or an SGLT2 inhibitor or a GLP-1 agonist and you will directly impact those things.

你可以服用二甲双胍、SGLT2抑制剂或GLP-1受体激动剂，这些药物将直接作用于那些目标。

I've decided to stay away from metformin and rapamycin.

我决定远离二甲双胍和雷帕霉素。

I think there's definitely a lot of crossover between, like, for example, I know metformin does inhibit gluconeogenesis, and so does a bunch of other, like, well-known type 2 diabetic medications that are prescribed.

我认为有很多交叉点，比如我知道二甲双胍抑制糖异生，很多其他众所周知的2型糖尿病药物也有这种作用。

BARZILAI: When you exercise with or without  metformin, your muscle will have the same increased capacity, but the  muscle wouldn't be as big.

BARZILAI：当您使用或不使用二甲双胍锻炼时，您的肌肉的能力都增加，但肌肉不那么大。

And second, the only people taking metformin in this study were people with diabetes.

其次，这项研究中唯一服用二甲双胍的人是糖尿病患者。