Specifically, that club-headed myosin wants to get all up-close-and-personal with the actin.

具，棒状头肌球蛋白想近距离接触肌动蛋白。

Like the actin and myosin in our muscles that enable us to move.

就像我们肌肉中的肌动蛋白和肌球蛋白一样，们使我们能够移动。

Actin and myosin, the proteins of muscles, permit those bodies to move around.

肌动蛋白和肌球蛋白， 肌肉的蛋白质， 允许这些身四处移动。

They've got their own famous coupling — a pretty pair of tiny protein strands called actin and myosin.

们有自己著名的联结——一对漂亮的微小蛋白质链，叫做肌动蛋白和肌球蛋白。

But the only myosin heads that can bind to those newly exposed sites are ones that are ready for action.

但是唯一能与这些新露的部位结合的肌球蛋白头是那些准备好行动的。

Then comes a brief period of contraction, when the myosin heads are binding, and pulling, and releasing, over and over, and the muscle fibers contract.

然后是短暂的收缩，这时肌球蛋白头一遍又一遍地结合、拉动和释放，肌肉纤维收缩。

They're divided lengthwise into segments called sarcomeres, which contain two even tinier strands of protein — two different kinds of myofilaments called actin and myosin.

们在纵向上被分成称为肌节的部分，其中包含两股更小的蛋白质——两种不同的肌丝称为肌动蛋白和肌球蛋白。

At this point, the myosin is totally stoked, because the bodyguards that have been frustrating it are in for a big, irresistible distraction.

在这一点上，肌球蛋白完全兴奋起，因为一直丧的保镖会有一个巨大的、不可抗拒的分心。

A sarcomere contains both thin filaments, made up mostly of two light and twisty actin strands, and thick filaments, composed of thicker, lumpy-looking myosin strands.

肌节既包含细丝，主要由两条轻盈而扭曲的肌动蛋白链组成，也包含粗丝，由更厚、看起块状的肌球蛋白链组成。

When those channels are thrown open, the calcium stored inside rushes into the rest of the cell, and finally myosin is like, YES! Here we go!

当这些通道打开时，储存在其中的钙会涌入细胞的其余部分，最后肌球蛋白就像，是的！开始了！

So after all that, with the myosin primed for action and the bodyguards out of the way, the myosin finally binds to actin, and it is beautiful.

经过这一切，当肌球蛋白准备好行动，保镖离开，肌球蛋白最终与肌动蛋白结合，这真是太美了。

That tension means myosin and the calcium pumps are burning up the muscle cells' ATP, and the finite supply of ATP is what makes it impossible to maintain vigorous muscle activity indefinitely.

这种张力意味着肌球蛋白和钙泵正在燃烧肌肉细胞的三磷酸腺苷，而三磷酸腺苷的有限供应使得肌肉活动不可能无限期地保持旺盛。

But soon the fiber slides back down into the relaxation period, when the calcium gets pumped back into the sarcoplasmic reticulum, and the actin and myosin stop the binding cycle, and the muscle relaxes.

但很快，纤维滑回松弛期，此时钙被泵入肌浆网，肌动蛋白和肌球蛋白停止结合循环，肌肉放松。

If another action potential travels down before that can happen, even more calcium gets released, which ends up exposing more actin for myosin to bind to, and that means more force in that fiber.

如果另一个动作电位在此之前下降，更多的钙被释放出，最终露出更多的肌动蛋白结合肌球蛋白，这意味着纤维中有更多的力量。

You'd also re-learn that your skeletal muscles are constructed like a rope made of bundles of protein fibers, and that the smallest strands are your actin and myosin myofilaments.

你还会重新了解到你的骨骼肌就像一根由成束蛋白质纤维组成的绳子，最小的链是你的肌动蛋白和肌球蛋白肌丝。

That binding causes another shape change. But this time, it causes the myosin to release from the actin, in a tear-jerking scene like some microscopic re-creation of the finale from Titanic.

这种结合导致了另一种形状变化。但这一次，导致肌球蛋白从肌动蛋白中释放出，这是一个催人泪下的场景，就像泰坦尼克号结局的微观再现。

Because this is when the myosin breaks down its new molecule of ATP into ADP and a phosphate, which moves it into the armed position yet again, getting it ready for its next rendezvous.

因为这是肌球蛋白将其新的 ATP 分子分解成 ADP 和磷酸盐的时候，这使再次处于武装状态，为下一次会合做好准备。

When they bind, the myosin releases all that stored energy, and — in the excitement of it all — the myosin changes shape. It pulls on its precious actin strand, kind of like pulling a rope hand over fist.

当们结合时，肌球蛋白释放所有储存的能量，在兴奋中，肌球蛋白改变形状。拉着珍贵的肌动蛋白链，有点像用手握住拳头拉绳子。

So the calcium latches on to the troponin and causes it to pull the other bodyguard protein — the tropomyosin — away from the sites on the actin strands that the myosin really wants to get its paws on.

所以钙锁住肌钙蛋白，并使其将另一种保护蛋白——原肌球蛋白——从肌球蛋白真正想要抓住的肌动蛋白链上的位置拉走。

When a myosin head does that, it moves into an extended position, kinda like a stretched spring — still holding on to the ADP and phosphate, and still storing the energy that was released when they were broken apart.

当肌球蛋白头这样做时，会移动到伸展的位置，有点像被拉伸的弹簧——仍然抓住 ADP 和磷酸盐，仍然储存们破裂时释放的能量。