But if it happens in certain genes that are important in cancer, like oncogenes or tumor suppressor genes, it can create deadly cancers like skin cancer.

但是如果它发生在某些对症很重要的中，比如或肿瘤抑制，它会产生命的症，比如皮肤。

The results showed that patients whose driver oncogenes were specifically targeted lived, on average, a year longer than those who received standard chemotherapy.

结果显示其子得到针对性地治疗的患者存活了，平均来说他们比那些接受标准化疗的患者多活一年。

Oncogenes help cells grow and proliferate, while tumor suppressor genes slow down cell growth and proliferation.

加速细胞生长增殖，而抑使细胞生长增殖变慢。

When proto-oncogenes, like epidermal growth factor receptor and RAS, are activated, it turns them into oncogenes that promote cell division.

当原（如表皮生长子受体、RAS）被激活时，它们就变成了促进细胞分裂的。

Fusobacteria is another genus of bacteria in the mouth that produces excessive immune responses and activates oncogenes.

梭杆菌属是口腔中另一种会引发过度免疫应答、激活的细菌。

So oncogenes or mutated tumor suppressor genes allow cells to keep growing uncontrollably resulting into tumors.

此，或突变的抑使细胞不受控制地增长，导肿瘤发生。

With mutations, proto-oncogenes become oncogenes, and these overstimulate the cell growth.

随着突变，原变为，这些过度刺激细胞生长。

So both an MYCN amplification or ALK gene fusion, where the oncogene is " turned on, " or a PHOX2B and chromosome 1 and 11 deletions, where tumor suppressor genes are " turned off, " can potentially cause uncontrolled cell growth.

此，MYCN扩增或ALK的融合，即被激活，或PHOX2B与1号、11号染色体缺失，即抑的失活，都可能导细胞生长不受控制。

One new treatment relies on a test to identify damaged genes called oncogenes that allow cancer cells to grow and spread.

一种新疗法是识别出名为的破损，这种能使得细胞发展和蔓延。

Oncologist Mark Kris from Memorial Sloan Kettering Cancer Center led a study that examined the role oncogenes play in the spread of cancer.

史隆凯特林症中心的肿瘤专家马克·克里斯负责了一项检验在症蔓延中所起作用的研究。

When oncogenes are turned on the cell is told to multiply rapidly.

当原被激活时，细胞就会被指令快速增殖。

These activate oncogenes, genes with the capacity to cause cancer, which drive abnormal cell proliferation or deactivate the body's natural tumour suppressor genes.

这些物质会激活， 即那些具有引发症能力的，它们推动异常细胞增殖， 或使人体天然的肿瘤抑制失活。

Unlike other targetable oncogene drivers in NSCLC, KRAs G12C is most common in smokers Until recently, KRAS was an undruggable target.

与 NSCLC 中的其他靶向驱动素不同，KRA G12C 在吸烟者中最常见。直到最近，KRAS 仍是一个不可药物治疗的靶点。

When your oncogenes get corrupted,   they basically turn on again.

当你的原发生变异时，它们本上就会重新激活。

Abnormal cell division can occur either when active oncogenes are expressed or when tumor suppressor genes are lost.

当活性表达或肿瘤抑制丢失时，可发生异常细胞分裂。

If several oncogenes are driven into action, the cell, unable to turn them off, becomes cancerous.

如果几个被激活，细胞无法关闭它们，就会变成细胞。

The result is that the cell receives a constant message to divide. This dominant " gain of function gene" is often called an oncogene.

结果是细胞接收一个恒定的消息进行不断分裂。这种显性的" 获得功能" 通常被称为。

52 This suggests oncogene addiction, as seen occasionally and originally when first-generation EGFR-TKIs were withdrawn from patients with EGFR mutations.

52 这表明成瘾，正如最初在从 EGFR 突变患者体内撤回第一代 EGFR-TKI 时偶尔看到的那样。

The second crucial mutation can happen in your  oncogenes.

第二个关键突变可能发生在你的原中。

Anything from cosmic rays to radiation to diet may activate a dormant oncogene, but how remains unknown.

从宇宙射线到辐射再到饮食，任何素都可能激活一个休眠的，但具体机制仍然未知。