Ok, now, when osteoclasts break down bone faster than the osteoblasts can rebuild it, it results in the lowering of the bone mass and eventually in osteoporosis.

那么，当破骨分解骨骼速度比造骨建骨骼更快时，骨量就会减少，最终导致骨质疏松。

When osteoblasts come in, they secrete a glue-like cocktail of collagen, as well as enzymes that absorb calcium, phosphate, and other minerals from the blood.

当骨进入时，它们分泌胶原蛋白以及从血液中吸收钙、磷酸盐和其他矿物质酶。

So an osteoblast in your bone becomes an osteocyte — ditto for chondroblasts becoming chondrocytes.

所以你骨骼中骨就变了一个骨。——软骨母为软骨也是如此。

Osteosarcomas arise from osteoblasts of different sizes - called pleomorphic - and these cells produce too much osteoid tissue.

骨肉瘤源于大小不同骨（多形性）；这些会产生过多类骨织。

But, for reasons that we don't understand yet, the osteoclasts actually increase their rate of bone resorption in low gravity, while the osteoblasts dial back on the bone formation.

但是，由于我们还不明白原因，破骨实际上在低力下增加了骨吸收速度，而骨则减少了骨形。

To build bone, osteoblasts secrete osteoid, which is an organic matrix made of type 1 collagen.

在构建骨过程中，骨分泌类骨质，它是一种由1型胶原有机质。

Osteoblasts — from the Greek words for " bone" and " germ" or " sprout" — are the bone-building cells, and they're actually what construct your bones in the first place.

骨——来自希腊语中" 骨" 和" 胚芽" 或" 芽" 意思——是骨生，它们实际上是构你骨骼首要因素。

Eventually osteoblasts get activated and a process called ossification will start, which is when the fibrous tissue turns to bone.

最后骨活化，骨化过程启动，纤维织最终转化为骨织。

And finally we got an introduction to the process of bone remodeling, which is carried out by crews of osteocytes, osteoblasts, and osteoclasts.

最后，我们得到了骨骼塑过程介绍，这是由骨、骨和破骨团队进行。

This means that osteoblasts don't have enough calcium and phosphate to deposit into the organic matrix.

这意味着骨没有足够钙和磷可以沉积到骨有机质中。

So while your osteoblasts are the bone-makers, your osteoclasts are the bone-breakers — which is a kind of violent image. Maybe think of them as like a bone-breaker-downer.

所以当你骨是骨骼制造者，你破骨是骨骼破坏者——这是一种暴力形象。也许可以把它们想象一个碎骨剂。

Now, for bones to grow and develop properly, special bone cells, called osteoblasts, are hard at work.

在骨正常生长发育过程中，有一种特殊骨，骨，了至关要作用。

From your time in the womb until you're about 25, your osteoblasts keep laying down more collagen and more calcium phosphate, until your bones are fully grown and completely hardened.

从你在子宫里时候到你大约 25 岁，你骨不断分泌更多胶原蛋白和磷酸钙，直到你骨骼完全生长和完全硬化。

Picture a scaffold of collagen put together by these osteoblast construction workers.

想象一下，这些骨建筑工人正在装一个由胶原蛋白构支架。

And in the study published this week, these researchers found that cardiac fibroblasts can also become cells that act just like osteoblasts, the cells responsible for depositing minerals in your bones.

而在本周发表研究中，这些研究人员发现， 心脏纤维也可以变像骨母一样， 而骨母是负责在骨骼中沉积矿物质。

This is a subcutaneous once a month drug that works upstream of osteoblasts to increase bone formation and to a lesser extent, inhibit bone resorption.

这是一种每月一次皮下注射药物， 作用于骨上游， 以促进骨形，并在较小程度上抑制骨吸收。

Hydrochlorothiazide boosts calcium retention in the kidney and directly stimulates osteoblast differentiation, therefore decreasing mineral bone loss.

氢氯噻嗪促进肾脏中钙保留且直接刺激造骨分化，因此减少骨质流失。

Other benign tumors are osteoblastomas and osteoid osteomas, both of which arise from osteoblasts.

其他良性肿瘤包括骨瘤、骨样骨瘤，两者均源于骨。

They're like the construction foremen of your bones, passing along commands to your skeleton's two main workhorses: the osteoblasts and the osteoclasts.

它们就像你骨骼建筑工头，将命令传递给你骨骼两个主要主力：骨和破骨。

Importantly, ectopic expression of c-Fos in H2-c-fosLTR transgenic mice drives osteoblast and chondrocyte proliferation resulting in osteosarcoma and chondrogenic sarcoma.

要是，H2-c-fosLTR转基因小鼠中c-Fos异位表达驱动了骨和软骨增殖，导致了骨肉瘤和软骨肉瘤形。