Eventually the pancreas gets damaged, because backed-up digestive enzymes degrade the cells lining the pancreatic ducts, causing local inflammation.

最终胰腺受损，因为储备的酶胰腺导管内的细胞，导致局限性炎症。

Cholecystokinin stimulates acinar cells in the pancreas to secrete digestive enzymes that travel through the pancreatic ducts and into the duodenum.

胆囊收缩素也能刺激胰腺的腺泡细胞产生酶；酶从胰腺导管排出，进入十二指肠。

This happens because thick secretions jam up the pancreatic ducts, not allowing digestive enzymes to make it to the small intestine.

因为粘稠的分泌物阻塞在胰腺导管中，使其无法酶分进入小肠。

To digest a meal, these zymogens are released into the pancreatic duct, and delivered to the small intestine where they are activated by the protease trypsin.

当食物时，这些酶原释放入胰管，然后进入小肠，在那里它们胰蛋白酶激活。

Now, to prevent the hydrochloric acid from the stomach from damaging the intestinal mucosa, enteroendocrine cells also secrete another hormone, called secretin, which stimulates the pancreatic duct cells to secrete water and bicarbonate.

为避免胃部产生的胃酸对小肠粘膜造成损伤，小肠内分泌细胞还可分泌胰泌素；它可以刺激胰腺导管细胞分泌水和碳酸氢盐。

When the pancreatic acinar cells are damaged or the the pancreatic ducts are blocked, often because of alcohol abuse or gallstones, the inactive zymogens that the pancreas produces can be prematurely converted to active digestive enzymes.

通常由酒精滥用或胆结石导致的胰腺腺泡细胞受损或胰管阻塞时，胰腺产生的无活性酶原可过早转为活性酶。