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It seems reasonable to conclude that Toosendanin is a presynaptic blocking agent.

果表明,川楝素是一个选择性地用于突触前的神经肌肉传递阻

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Crash Course 解剖生理学篇

This set-up has two principal parts: The cell that's sending the signal is the presynaptic neuron, and it transmits through a knoblike structure called the presynaptic terminal, usually the axon terminal.

这种设置有两个主要部分:发送信号的细胞是触前,它通过一个叫做触前终端的节状结构行传输,通常是轴终端。

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医学英语

Its mechanism of action is poorly understood, however, some of the speculated ones are that it prevents dopamine reuptake, facilitates presynaptic dopamine release, and blocks glutamate NMDA receptors.

然而,人们对其作用机制知之甚少,其中一些推测是它能阻止多巴胺再摄取,触前多巴胺释放,并阻断谷氨酸盐NMDA受体。

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Osmosis-精心理

Cocaine increases the release of certain neurotransmitters, but it's biggest effect is blocking reuptake receptors on presynaptic axon terminals, and both actions keep neurotransmitters like dopamine, norepinephrine, and serotonin in the synapse longer and increases their effects.

可卡因一些特定递质的释放,但它最大的作用是阻止触前终端受体的“再摄取”;两种作用都能使得递质,如多巴胺、去甲肾上腺素与5-HT,在触间隙存留时间延长,从而加强他们的作用。

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