Difloxacin is the fluorinated quinolone approved for use in veterinary only. compared to ciprofloxacin,it provided with better pharmacokinetical and pharmacodynamical feature.

二氟属于兽医专用药物，并且有优于环的药动学特征，有良好的应用。

Finally, we gained four esterifiable quinolone analogues (compounds 22 to 25) by modifying the structures of compound 3, 14 and 16 on 3 position.

时利用所合成的化合物3，14，16为模板，对它们的3位羧基进行了酯化反应合成了4个喹诺酮酯类化合物：化合物22—25。