There's a 5-alpha reductase deficiency that causes changes in testosterone metabolism.

存在5-α还原酶缺乏症，这会导致睾酮代谢的变化。

Pretty quickly, it zeroed in on HMG-CoA reductase.

很快，它就锁定了HMG-CoA还原酶。

You're right, it is similar to 5-alpha reductase, which is the, sorry, inhibition, which is very similar to another drug called finasteride, which is something that men can be prescribed for benign prosthetic hypertrophy.

你说得对，这类似于5-α还原酶的抑制，这与另一种叫做非那雄胺的药物非常相似，这种药物开给男于治疗良腺增生。

Because I've covered content on that as well in the past, talking about the dangers of Lion's Mane as a 5-alpha reductase inhibitor.

因为我过去也讨论过狮鬃菇作为5-α还原酶抑制剂的危险。

BOLTS2, an ML model specifically designed to predict how strongly a molecule will bind to a target protein, in this case, HMG-CoA reductase.

BOLTS2，一种专门于预测分子与靶标蛋白（本例中为HMG-CoA还原酶）结合强度的机器学习模型。

So, first of all, DHT is the primary, you could call it the primary male androgen that's actually derived from testosterone through the 5-alpha reductase enzyme.

所， 首先，双氢睾酮是主要的男雄激素， 它实际上是由睾酮通过5α还原酶酶转化而来的。

And so it is likely that the lion's mane is actually causing problems via that same mechanism as finasteride, because they're both 5-alpha reductase inhibitors.

因此， 很能是狮子鬃毛通过与非那雄胺相同的机制引起了问题，因为它们都是5-α还原酶抑制剂。

But if we talked about earlier, you have more 5-alpha reductase, more aromatase in the testes.

但正如我们之所讨论的，睾丸内含有更多的5-α还原酶和芳香化酶。