4.So focal segmental glomerulosclerosis is a type of nephrotic syndrome, that's helpful, but why does the glomerulus develop segmental sclerosis in the first place?
5.Comparatively, circumferential joints between segmental rings are more pron to dislocation and rotation, resulting in the sharp deformation and steps.
11.Alright so on histology, there'll be segmental sclerosis and hyalinosis of the glomeruli, and under electron microscope, there's effacement of the foot processes of the podocytes.
12.E denotes Young's modulus of the segmental ring, I is theareamomentofinertiaofthetunnelcross-section, G is the shear modulus, A is the tunnel cross-sectional area.
13.Segmental means that only a segment, or part of the glomeruli is affected, and focal means that among all those glomeruli in the kidney, only some are affected.
14.When the tunnel stress field reaches a certain threshold, segmental rupture, leakage, segmental joint opening, and varying degrees of other damage will occur.
17.Each segmental ring is treated as a Timoshenko beam, and each circumferential joint is considered by two mechanical springs including the shearing spring and the rotation spring.
18.This model incorporates an improved subgrade modulus and treats each segmental ring as a Timoshenko short beam, with each circumferential joint modeled by two mechanical springs.
19.However, the Timoshenko beam may provide a more accurate representation of the segmental ring to model the ring dislocation, given that the height of the ring is significantly greater than its width.
20.Alright, so as a quick recap, focal segmental glomerulosclerosis is a nephrotic syndrome characterized by sclerosis and hyalinosis in some, but not all, glomeruli, and usually only affects part of the glomeruli that it affects.