Fluids may increase intra-erythrocyte free water and hinder the formation of sickling.
液体治疗可使内自水增,阻止镰状变形。
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HbS carries oxygen perfectly well, but when it is deoxygenated, HbS changes its shape, which allows it to aggregate with other HbS proteins and form long polymers that distort the red blood cell into a crescent shape - a process called sickling.
HbS很好携氧,氧时,HbS会改变其形状,从而使其与其它HbS蛋白聚集形成长链多聚体,进而使红细胞扭曲变形成新月型,该过程称为镰变。