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Fluids may increase intra-erythrocyte free water and hinder the formation of sickling.

液体治疗可使内自水增阻止镰状变形。

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Osmosis-血液肿

Repeated sickling of red blood cells damages their cell membranes and promotes premature destruction.

反复镰变会损伤红细胞膜,使其过早破坏。

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Osmosis-血液肿

HbS carries oxygen perfectly well, but when it is deoxygenated, HbS changes its shape, which allows it to aggregate with other HbS proteins and form long polymers that distort the red blood cell into a crescent shape - a process called sickling.

HbS很好携氧,氧时,HbS会改变其形状,从而使其与其它HbS蛋白聚集形成长链多聚体,进而使红细胞扭曲变形成新月型,该过程称为镰变。

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