Hepatic stellate cells (HSteC) are intralobular connective tissue cells presenting myofibroblast-like or lipocyte phenotypes.
肝脏星形是小叶内结缔组织
,
现肌
纤维
或脂肪
形态。
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When activated, the stellate cells lose vitamin A, proliferate, and start secreting secreting transforming growth factor beta1, or TGF-beta, which then causes them to produce collagen, which is the main ingredient in extracellular matrix, fibrosis, and scar tissue.
激活后的星形失去维生素A,并且开始大量增生,
泌转
生长因子ß,即TGF-ß,随之导致其生成胶原;胶原是
外基质、纤维
和疤痕组织的重要成
。