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Lenalidomide, a novel analogue of thalidomide, belongs to the immunomodulatory drug (IMiD) for the treatment of multiple myeloma and myelodysplastic syndrome.

来那度种新型免疫调节药,主要用治疗多发性骨髓瘤和骨髓常综合征。

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Galibi, Galicia, Galician, Galilean, Galilean telescope, Galilee, Galilei, Galileo, galimatias, galingale,

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3G, 401(K), a,

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And molecules like thalidomide are the same way.

多胺这样的分也是如此。

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经济学人(汇总)

Don McCullin's unsparing portraits from war zones, or the dangling body-harness of a thalidomide child.

唐·麦卡林对战争地区的无情描绘,或者利多胺儿童悬空中的身体吊带。

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What researchers didn't know at the time was that there were actually two versions of the thalidomide molecule.

那时的研究员们不知道多胺分有两个变体。

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Even though they were now aware that thalidomide was a problem, scientists still didn't know why.

即使他们已经意识到了是多胺的问题,但那时的科学家仍然不清楚中原因。

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By 1961, Lenz had proven the link between thalidomide and the birth defects, and it was pulled from the shelves.

到1961年,Lenz证明了多胺与先天性缺陷之间的联系,该下架。

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TED-Ed(视频版)

As public awareness of the thalidomide tragedy grew, the quiet scientist became a media sensation.

随着公众对沙利度胺悲剧的意识增强,这位沉默寡言的科学家成了媒体的轰动人物。

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TED-Ed(视频版)

Kelsey found its data on thalidomide’s absorption and toxicity inadequate.

Kelsey 发现有关沙利度胺吸收和毒性的数据不足。

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In thalidomide, for example, the chiral center is a carbon atom attached to one of the rings.

例如多胺中,手性中心是一个吸附一个结构环上的碳原

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SciShow - Chemistry

Even though they were now aware that thalidomide was a problem, scientists still didn’t know why.

尽管他们现意识到沙利度胺是个问题, 但科学家们仍然不知道原因。

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But it turns out that thalidomide's R enantiomer can actually switch to the S version while inside the human body.

但事证明,多胺中的R对映体人体内还是可以转换成S变体。

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But in 1998, the FDA did approve thalidomide, almost forty years after rejecting it based on the birth defect problems.

但1998年,由于先天性缺陷问题而被禁的近40年后,食品及物管理局的确批准了多胺的使用。

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TED-Ed(视频版)

Merrell executives complained that stubborn and nit-picking Kelsey was the problem, not thalidomide.

Merrell 的高管们抱怨说,固执和吹毛求疵的凯尔西才是问题所,而不是沙利度胺。

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SciShow - Chemistry

What researchers didn’t know at the time was that there were actually two versions of the thalidomide molecule.

当时研究人员不知道的是沙利度胺分际上有两个版本。

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SciShow - Chemistry

But it turns out that thalidomide’s R enantiomer can actually switch to the S version while inside the human body.

但事证明,沙利度胺的 R 对映异构体际上可以人体内转换为 S 版本。

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TED-Ed(视频版)

In November 1961, thalidomide was pulled from the German market.

1961 年 11 月,沙利度胺退出德国市场。

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TED-Ed(视频版)

Merrell had expected a quick, affirmative reply so it could launch thalidomide for the holiday season, when sedative sales soar.

Merrell 曾期望得到快速、肯定的答复,以便镇静剂销量飙升的假期推出沙利度胺。

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TED-Ed(视频版)

As Kelsey reviewed and rejected each new application, news of thalidomide’s adverse side effects began to surface.

当凯尔西审查并拒绝每一项新申请时,沙利度胺的不良副作用的消息开始浮出水面。

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Meaning that even if they'd isolated 100% pure R thalidomide, it still wouldn't be safe for pregnant women.

这意味着即使他们将R多胺完全隔离出来,对孕妇而言,依旧不安全。

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BBC 听 2012年9月合集

The pharmaceutical company Gruenenthal produced thalidomide in the 1950s and 60s to help pregnant women suffering from morning sickness. With the details, here is Mike Wooldridge.

公司Gruenenthal于五六十年代生产了立多胺来帮助孕妇免于晨吐。麦克·沃特里报道。

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BBC 听 2012年9月合集

The apology came as the chief executive of the Gruenenthal Group Harald Stock unveiled a bronze statue symbolising a boy born without a limbs because of thalidomide.

Gruenenthal集团总裁哈拉尔·司多克揭开一座象征因立多胺而出生时就缺少四肢的男孩铜像,然后对此事表示道歉。

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galirubin, galizinit, galjoen, gall, gall bladder, gall midge, gall stone, gall wasp, Galla, gallabiya,

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3G, 401(K), a,
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