The acetylation and deacetylation of histone is charged by a pair of protea se with antistatic function on each other,which are histone transacetylase and histone deacetylase.

组蛋白乙酰乙酰由对功能相的蛋白酶——组蛋白乙酰基转移酶组蛋白乙酰酶负责。