High levels of uric acid can also cause gouty arthritis, most commonly in the first metatarsal joint which is the base of the big toe.

导致痛风性关节炎，最常发于第一跖骨关节即拇趾的基底部。

Mainly, urea and uric acid producing even more ammonia.

同时素和更多的氨。

The underlying cause is hyperuricemia— too much uric acid in the blood, which results in the formation of sharp, needle-like crystals, in areas with slow blood flow like the joints and the kidney tubules.

引起痛风的原因是血症，即血液中的含量过，过多的在血流缓慢的地方，如关节腔和肾小管，形成尖锐的细针样结晶。

The fatty acids, urea, uric acid and lactate in the sebaceous film protect and hydrate the skin.

皮脂膜中的脂肪、素、和乳对皮肤有着保护和滋润作。

Finally, there are some rare stones made of xanthine, which, just like uric acid, is a byproduct of purine breakdown.

最后，还有由黄嘌呤形成的罕见结石，同一样，是嘌呤分解的副物。

Individuals with chronic gout are also at an increased risk for developing kidney stones made of uric acid, as well as urate nephropathy, which is when urate crystals deposit in the interstitium of the kidney.

慢性痛风的病人罹患性肾结石以及性肾病的风险也升；性肾病中，结晶沉积于肾脏间质。

Uricosuric medications, like probenecid, increase excretion of uric acid by the kidneys.

促排泄药物，如丙磺舒，提的肾脏排泄。

These stones, also like uric acid stones, are red-brown in color and radiolucent under an X-ray.

这类结石也像结石一样，呈红棕色，X射线可透过。

Xanthine oxidase is an enzyme involved in the breakdown of purines to uric acid, so inhibiting this enzyme results in less uric acid production.

黄嘌呤氧化酶负责分解嘌呤为，所以抑制这个酶，就可以减少的成。

The most common type of stones are calcium oxalate stones, though other types include uric acid stones and struvite stones.

草钙结石是最常见的类型，其他类型的结石有结石和感染性结石。

Since uric acid is a breakdown product of purines, a very common reason for high levels of uric acid is consuming lots of purines.

由于是嘌呤的分解物，故是大量摄入嘌呤的结果。

There are also medications that help to decrease uric acid levels, which include xanthine oxidase inhibitors like allopurinol.

也有一些药物可以帮助降低含量，包括黄嘌呤氧化酶抑制剂，如别嘌醇。

A few of the common ones being aminoglycosides—a group of antibiotics, heavy metals like lead, myoglobin released from damaged muscles, ethylene glycol—essentially anti-freeze which is naturally sweet tasting and therefore a risk for poisoning children, radiocontrast dye, and uric acid.

其中一些常见毒素是氨基糖苷类抗素、重金属如铅、肌肉受损释放的肌红蛋白、乙二醇、放射性对比剂以及等；其中乙二醇本质上是防冻剂，有甜味，因此是毒害孩子的危险因素。

At a physiologic pH of about 7.4, uric acid loses a proton and becomes a urate ion, which then binds sodium and forms monosodium urate crystals.

在理环境下，体液的pH值约为7.4，此时失去一个质子，变为离子；离子与钠离子结合，形成单钠盐结晶。

Another way crystals could form is from decreased clearance of uric acid, which can result from dehydration from not drinking enough water or from consumption of alcoholic beverages, both of allowing uric acid to precipitate out.

结晶的另一种成因是清除减少，如由饮水过少引起的脱水、大量饮酒等，这都让更容易析出。

At a physiologic pH, uric acid loses a proton and becomes a urate ion, which then binds sodium, forming monosodium urate which crystallizes and ultimately forms uric acid stones.

理PH值下，失去一个质子变成盐离子，随之与钠结合，形成单钠盐，结晶后最终形成结石。

There are also uric acid stones which are red-brown in color and radiolucent under an Xray, meaning that they're transparent to x-rays and don't show up very well.

另外还有呈红棕色的结石，在X光片上不显影，说明X射线可以穿过它们，不能很好地显影。

Finally, there are some medications like thiazide diuretics and aspirin which can also increase the levels of uric acid and therefore the risk of gout.

最后，一些药物，如噻嗪类利剂、阿司匹林，也提水平，从而诱发痛风。

This inflammation and local pain's ultimately caused by white blood cells, or leukocytes, which migrate to the site to help eliminate uric acid and release proinflammatory chemicals, including cytokines.

炎症和疼痛根本上都是由白细胞引起的；白细胞从血液迁移至关节腔，帮助清除沉积的，并释放大量的炎症因子，包括细胞因子。

Also, some individuals have a genetic predisposition to overproduction of uric acid while others with chronic kidney disease may be unable to excrete the uric acid.

同时，某些个体遗传易感，倾向于过量成；而慢性肾病病人因其无法正常排泄，也可能诱发痛风。