Similarly in diabetes, individuals can't make enough insulin, so the cells are effectively " starving" even though they are surrounded by glucose in the blood.
In Prader-Willi, the hypothalamus has issues secreting gonadotropin releasing hormone and growth hormone releasing hormone as it should, which can cause decreased sex hormone levels and short stature, respectively.
医学百科 The Medicine Book (Big Ideas Simply Explained)
In 1910, British physiologist Edward Sharpey Schaeffer proposed that diabetes developed when a substance produced by the beta cells in the islets of Langerhans was deficient.
People with type I diabetes don't make enough insulin, so when they eat a meal—especially a meal with a lot of potassium— that potassium sits in the blood instead of being taken into cells, and this causes hyperkalemia.