In rare cases, essential thrombocythemia can develop into myelofibrosis and acute leukemia.

少数原小板增多症案例会展为骨髓纤维化白病。

All that being said, in situations where somebody produces too much aldosterone, like primary hyperaldosteronism, then there's more potassium secretion by the principal cells and excreted, and therefore less potassium is retained, leading to hypokalemia.

说了这么多，在某人产生了太多醛固酮的情况下，比如原醛固酮增多症，更多的钾被主细胞分泌并排泄，这意味着更少的钾被保留，导致了低钾症。

The most common primary cause is called idiopathic hyperaldosteronism, because the zona glomerulosa has an increase in the number of cells secreting aldosterone, but it's not really clear why this happens.

最常见的原病因称为醛固酮增多症：这是由于球状带分泌醛固酮的细胞数量增加，但目前尚不清楚为什么会生这种情况。

Hyperaldosteronism can happen due to primary causes which is where the adrenal gland itself is responsible for the excess production of aldosterone.

醛固酮增多症可以是原的，即肾上腺本身产生了过量的醛固酮。

But more commonly, essential thrombocythemia is usually found unintentionally when elevated platelet levels are found on a routine complete blood count.

但原小板增多症常常是做常规全细胞计数时现小板增多，而被无意现的。

Treatment of essential thrombocythemia depends on risk of blood clots.

原小板增多症的治疗取决于栓形成的风险。

Now, some individuals with essential thrombocythemia can have symptoms like fatigue, headache, dizziness, nausea, tinnitus or ringing in the ears, and numbness in the hands and feet.

有些原小板增多症的患者，会有疲乏、头痛、晕眩、恶心、耳鸣（耳朵里有声音）以及手足麻木等症状。

So I think where I'm looking at into the future is say you get somebody with new onset hypertension or prehypertension, perform aldosterone read and profiling, identify those individuals as subclinical PA.

所以我认为未来我关注的方向是， 比如遇到新高压前期高压的患者，进行醛固酮检测和分析，识别出那些亚临床原醛固酮增多症的个体。

So as Greg mentioned earlier, so in this study found in normal population from the era using the immunoassay to be 12 and a half, so definitely lower for typical threshold for diagnosis of PA.

正如格雷格先前所提， 本研究在正常人群中采用免疫检测法得出的数值为12.5，这显然低于诊断原醛固酮增多症（PA）的常规阈值。

And so our hypothesis was that independent of blood pressure, subclinical forms of primary aldosteronism would be associated with adverse cardiovascular events such as heart attack, stroke, heart failure, cardiovascular death.

因此， 我们的假设是， 无论压水平如何，原醛固酮增多症的亚临床形式都与不良心管事件相关，如心脏病作、中风、心力衰竭及心管死亡。

And now let's move to that featured discussion about primary aldosteronism.

现在，让我们转向关于原醛固酮增多症的专题讨论。