Finally, we gained four esterifiable quinolone analogues (compounds 22 to 25) by modifying the structures of compound 3, 14 and 16 on 3 position.
同时利用所
的化
3,14,16为模板,对它们的3位羧基进行了酯化反

了4个喹诺酮酯类化
:化
22—25。
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It's a multidrug resistant bacteria, and it can be treated with cephalosporins, aminoglycosides, fluoroquinolones, and carbapenems in case of beta-lactamase production; only with carbapenems in case of ESBL production; and with colistin, tigecycline or fosfomycin in case of carbapenemases production.
肺炎克雷伯杆菌也是一种多重耐药菌,如果产生β-内酰
,
以用头孢菌素、氨基糖苷类、
喹诺酮类以及碳青霉烯类药物治疗;如果产生ESBL,
以只应用碳青霉烯类进
治疗;如果产生碳青霉烯
,则应用多粘菌素、替加环素或磷霉素进
治疗。