Background : Bendamustine, a bifunctional alkylating agent with anticipated purin-like properties is active in metastatic breast cancer (MBC) patients.
If allopurinol toxicity occurs, options include other xanthine oxidase inhibitors, a uricosuric agent, or allopurinol desensitisation (the latter only in cases of mild rash).
To understand where the uric acid comes from, let's start with purines, which, together with pyrimidines, are nature's most common nitrogen-containing heterocycles.