Animal experiment and clinical study showed that low frequency electric stimulation on pedunculopontine nucleus (PPN) could obviously reduce the akinesis of PG.
It has been demonstrated that the abnormal hypoactivity and synchronized rhythmic discharge of globus pallidus neurons associate with akinesia and resting tremor in parkinsonism.
Abstract: Objective To investigate the changes in the firing activity of noradrenergic neurons in the locus coeruleus (LC) in a rat model of Parkinson disease (PD).