The more myostatin present, the lower the amount of muscle you can build.

肌抑素越多，肌肉量越多。

Myostatin is a regulating protein that alters the rate of muscle growth, creating a genetic muscle ceiling.

肌抑素是一种调节蛋白，通过制造肌肉外壁改变肌肉增长率。

As seen in other animals, the lack of myostatin can invoke unnatural amounts of muscle.

此亦见于其他动物中，肌抑素减少会导致肌肉量不正常增长。

The protein follistatin, has an antagonist effect to myostatin, diminishing myostatin's muscle limiting effect.

卵泡抑素蛋白与肌抑素存在拮抗作用，它能降低肌抑素对肌肉限制。

Yeah, I've had patients get folistatin gene therapy.

是，我有一些患者接受了卵泡抑素基因疗法。

Follistatin and myostatin modulators, but for adults, it's probably not going to be a really significant driving force.

卵泡抑素和肌肉生长抑制剂调节剂，但对于成年人来说， 可能不会成为非常显著驱动力。

With roughly 150 milligrams of epicatechin supplementation per day, the 6 middle-aged subjects saw a 16.6% myostatin decrease and a 49.2% follistatin increase.

每日 150 毫克表儿茶素补剂，使六位中年实验者肌抑素降低 16.6%，卵泡抑素则增长了 49.2%。

Fittingly, if your goal is to build muscle, you want myostatin reduced, but not to the point of completely removing it.

若你目标是增肌，你会希望减低肌抑素但又不想完全消除它。

If you look into what Follistatin does in structure with FSH, et cetera.

如果你深入研究卵泡抑素与促卵泡激素等在结构上作用。

But yeah, as far as like folistatin gene therapy, I think it's too early to recommend clinically.

不过，就目前而言，关于卵泡抑素基因疗法，我认为在临床上推荐它还为时过早。

But my main question with Follistatin gene therapy is, you know, What is the main goal with this?

但我对卵泡抑素基因疗法主要疑问是，你道，它主要目标是什么？

Well, the other thing is, physicians listening to this, please make this another reason to just look at cystatin C, please.

还有，听这个节目医生们，请再把这个当作一个理由，去关注一下胱抑素C。

Rather than beefing up an athlete's muscles, another new class of drugs, myostatin inhibitors, slow the routine breakdown of muscle tissue, offering an alternative way of increasing strength.

另一类新药，“肌抑素抑制剂”，它无法增强运动员肌肉，而是通过减缓肌肉组织常规分解来增强力量。

Cystatin C is a far more accurate way to measure and estimate GFR and you don't have this problem of getting the confounded creatine levels increased.

胱抑素C是一种更准确测量和估算肾小球滤过率（GFR）方法，你不会遇到肌酐水平被混淆而升高问题。

But going back to, you said before around the myostatin inhibitor, the bimagrumab, that one there, you say it was more effective than folistatin gene therapy.

回到之前提到肌肉生长抑制剂，比格鲁单抗， 你说它比卵泡抑素基因疗法更有效。

One thing that one would do clinically would get a cystatin C to correct and get a corrected GFR to see if it's within the normal range.

临床上会做一项检查是胱抑素C，以校正并获得一个修正后肾小球滤过率（GFR），看看是否在正常范围内。