First, we need to acknowledge the existence of creatine nonresponders people that due to them having naturally high creatine levels already or unfavorable muscle fiber compositions, we'll see little to no effect with creatine supplementation.

首先，我们需要承认有肌酸无反应——这由于体内肌酸水平本身较高，或者肌肉纤维类型不利于肌酸作用，因此补充肌酸后几乎没有效果。

The majority of this stage is really this deep non-responsive growth hormone recovery type sleep.

这一阶段大部分时间实际上是深度无反应生长激素恢复型睡眠。

I just posted this article about how to deal with PDE5 inhibitors, non-responsiveness.

我刚发了一篇文章，讲是如何应磷酸二酯酶5抑制剂无反应问题。

So to those people with chronic conditions, by definition, not responding to standard medication.

因此，于长期患病、按定义标准药物无反应。

Goodman and Gilman knew that it killed lymphocytes, a type of white blood cell, and administered it via intravenous injections to terminally ill blood cancer patients who hadn't responded to radiotherapy.

古德曼和吉尔曼知道它能够杀死淋巴细胞，即一种白细胞， 并通过静脉注射将其用于放射治疗无反应晚期血癌患者。

But this prevalence of overdoses where people don't respond to naloxone is And what does that suggest to you about the toxicity of the drug supply right now?

但这种们纳洛酮无反应过量用药普遍现象，又向我们揭示了当前药物供应毒性如何呢？老实说，这确实说明了很多问题，吧？

An inert hand or a lack of touch, is truly as serious a problem as we feel it is.

无反应手或缺乏身体接触，确实是我们所感受到样严重问题。

So this could be like a different kind of treatment maybe for people who don't respond to those medications.

因此，这可能是一种不同类型治疗方式，或许适用于现有药物无反应患者。

How devastating to self-confidence an inert hand can be in this situation.

这种情况下，一只无反应手自信心打击是多么巨大。

There is a version of ketamine that the FDA approved in 2019 to treat depression that didn't respond to our current treatments like SSRIs.

2019年，FDA批准了一种氯胺酮变体，用于治疗现有治疗（如SSRIs）无反应抑郁症。