The permeability of blood-brain barrier (BBB) was detected by Evans Blue (EB) leakage method, and the ultrastruncture of BBB, which contained astroglia, was observed under electron microscopy.
Well fibrosis is a process mediated by special cells called stellate cells, that sit between the sinusoid and hepatocyte, known as the perisinusoidal space.
Biopsies suggest that depending on the brain region, astrocytes regulate between 50 and 90% of human brain synapses in this way. Astrocytes meddling is thus the rule, not the exception.