Physicians like Sir Charles Locock hypothesized that sedative drugs might calm overactive brain activity, a theory he confirmed by treating seizures with a medication called potassium bromide.

像查尔斯·洛克克爵士医生假设镇静药物可能会平息度活跃大脑活动，他通使用做溴化钾药物治疗癫痫发作证实了理论。